TOX Antibody, anti-human/mouse, pure, REAfinity™

01MT11727

Clone REA473 recognizes the human and mouse TOX antigen, a member of an evolutionarily conserved DNA-binding protein family, and also known as thymocyte selection-associated HMG box protein. TOX is a thymic transcript that is highly upregulated in CD4+CD8+ double positive thymocytes. It is expressed in the thymus in a stage-specific regulated manner and in several immune-relevant cell subsets. TOX expression is also detected in other tissues, including liver, where it likely plays additional functions in regulating metabolic processes. It is part of the larger HMG-box superfamily of proteins,