TIGIT Antibody, anti-mouse, APC, REAfinity™

01MT12357

Clone REA536 recognizes the mouse T cell immunoreceptor with Ig and ITIM domains (TIGIT) antigen, a single-pass type I membrane protein which is also known as V-set and transmembrane domain-containing protein 3 (Vstm3). TIGIT belongs to a PVR family of type 1 proteins that also binds to CD155 and CD112 ligands. It is expressed on peripheral memory and regulatory CD4+ T cells and NK cells and is upregulated following activation on naive CD4+ T cells. Its interaction with CD155 induces tolerogenic dendritic cells that impaire T cell proliferation and inhibit IFN-γ production from responding T ce