T-bet Antibody, anti-human/mouse, Vio® B515, REAfinity™

01MT12080

The monoclonal antibody REA102 recognizes human and mouse T-bet, a Tʜ1-specific T-box 1 transcription factor. T-bet is considered to be an important regulator of Tʜ1 lymphoid development and is involved in class-switch recombination in B cells. It is widely expressed in hematopoietic cells such as B cells, T cell subsets, NK and NKT cells, and dendritic cells. Expression of T-bet is induced by Tʜ1 cytokine IFN-γ and T-bet further regulates the expression of cytokines including IFN-γ, IL-12Rβ, and IL-2. Additional information: Clone REA102 displays negligible binding to Fc receptors.