Slug Antibody, anti-human, PE, REAfinity™

01MT12027

Clone REA404 recognizes the human slug antigen, a zinc finger transcriptional repressor also known as SNAI2. Slug is an inducer of the epithelial to mesenchymal transition (EMT) which is a highly conserved developmental program activated during mesoderm formation and neural crest development. This program also promotes dissemination of single malignant cells from primary epithelial tumors. During EMT, cells discard their epithelial characteristics, including cell adhesion and polarity, reorganize their cytoskeleton and acquire a mesenchymal morphology and the ability to migrate. One of the hal