Rb pS807/pS811 Antibody, anti-human, APC, REAfinity™

01MT05516

Clone REA691 recognizes the human retinoblastoma (Rb) antigen phosphorylated at serines 807 and 811. The Rb protein is a tumor suppressor that plays a pivotal role in the negative control of the cell cycle and in tumor progression. It has been shown that Rb is responsible for a major G1 checkpoint, blocking S-phase entry, and cell growth. Loss of Rb functions may induce cell cycle deregulation, leading to a malignant phenotype. Rb negatively regulates transcription by forming complexes with members of the E2F transcription factor family. These complexes, when bound to E2F sites within certain