PTEN Antibody, anti-human/mouse, PE, REAfinity™

01MT02354

Clone REA270 recognizes the phosphatase and tensin homolog deleted on chromosome ten (PTEN) antigen, regardless of phosphorylation status. PTEN is a tumor suppressor gene which is also known as mutated in multiple advanced cancers 1 (MMAC1) or TGF-β–regulated and epithelial cell-enriched phosphatase (TEP-1). It has been found to be defective in a large number of human cancers like glioblastoma, breast, and prostate. In addition, germ-line mutations in PTEN result in the dominantly inherited disease Cowden syndrome. PTEN functions as a negative regulator of the phosphoinositide 3-kinase signali