Plexin-D1 Antibody, anti-human, APC, REAfinity™

01MT00847

Clone REA542 recognizes the human plexin-D1 antigen, a type I transmembrane glycoprotein that is a member of the D subfamily of semaphorin receptors. Plexin-D1 is amongst others the receptor for semaphorin 3E (Sema3E) which is a secreted molecule implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Plexin-D1 plays an important role in cell-cell signaling and in regulating the migration of a wide spectrum of cell types, and is able to trigger R-Ras inactivation, leading to axonal and cell repulsion in vitro. Moreover, it was shown that Sema3E mediates