PKCα pT497 Antibody, anti-human, PE, REAfinity™

01MT07365

Clone REA821 recognizes the PKCα antigen phosphorylated at threonine 497. PKCα has been reported to crossreact with PKCβ. PKCα is a serine- and threonine-specific protein kinase that can be activated by calcium and the second messenger diacylglycerol. It plays roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. PKCα is highly expressed in a number of cancer cells where it can acts as a tumor promoter and it is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Knockout stud