PepTivator® RAS G12R, premium grade

02MT00294

PepTivator® RAS G12R is a pool of lyophilized peptides, consisting of 15-mer, 10-mer and 9-mer sequences containing the G12R mutation. G12R is a common driver mutation that occurs with high frequency across various human cancer types. PepTivator® RAS G12R covers the mutated protein domain [MTEYKLVVVGARGVGKSALTIQLIQN] and contains every 15-mer, 10-mer and 9-mer peptide bearing the mutated amino acid. This diversity allows loading of HLA without prior knowledge of alleles. The proteins H-Ras, N-Ras, and K-Ras share 90% identity in their G domain (residues 1–166), and this peptide pool covers the