p120 Catenin pT916 Antibody, anti-human/mouse, APC, REAfinity™

01MT01724

Clone REA129 recognizes the T916-phosphorylated form of p120 Catenin, a prototypic member of subfamily of armadillo-domain (ARM) proteins. p120 ARM domain displays 22% homology to other ARM-domain proteins such as β-catenin and plakoglobin, which are basically cadherin binding proteins, suggesting the involvement of p120 in binding to cadherin. p120 associates with most classical (type I) and nonclassical (type II) cadherins via ARM repeats 1–7 and is localised at the cell junctions, where it constitutes the cadherin complex. Functions of p120 include regulation of stability of cadherins and