p120 Catenin pT310 Antibody, anti-human, APC, REAfinity™

01MT02593

Clone REA153 recognizes the threonine residue (T310)-phosphorylated form of p120 Catenin, a prototypic member of subfamily of Armadillo-domain (ARM) proteins. p120 ARM domain displays 22% homology to other ARM-domain proteins such as β-catenin and plakoglobin, which are basically cadherin binding proteins, suggesting the involvement of p120 in binding to cadherin. p120 associates with most classical (type I) and nonclassical (type II) cadherins via ARM repeats 1–7 and is localised at the cell junctions, where it constitutes the cadherin complex. Functions of p120 include regulation of stabilit