p120 Catenin pS879 Antibody, anti-human, APC, REAfinity™

01MT04680

Clone REA548 recognizes the S879-phosphorylated form of p120 catenin, a prototypic member of the subfamily of armadillo-domain (ARM) proteins. p120 ARM domain displays 22% homology to other ARM-domain proteins such as β-catenin and plakoglobin, which are basically cadherin binding proteins, suggesting the involvement of p120 in binding to cadherin. p120 associates with most classical (type I) and non-classical (type II) cadherins via ARM repeats 1–7 and is localised at the cell junctions, where it constitutes the cadherin complex. Functions of p120 include regulation of stability of cadherins