p120 Catenin pS288 Antibody, anti-human, APC, REAfinity™

01MT04603

Clone REA498 recognizes the human p120 catenin antigen phosphorylated at serine 288 (pS288). p120 catenin exists as four isoforms that range in size from 90 to 115 kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered expression contributes to malignancy. p120 catenin is a prototypic member of subfamily of armadillo-domain (ARM) proteins. The p120 ARM domain displays 22% homology to other ARM-domain proteins such as β-catenin and plakoglobin, which are basically cadherin binding proteins, suggesting the involvement of p120 in binding to cadherin. p120