ORN R-0002

99MT00185

TLR7 and TLR8 are members of the Toll-like-receptor (TLR) family, recognizing (virally derived) double- or single-stranded RNA, leading to activation of immune cells. ORN R-0002 activates specifically human TLR8 and induces a TLR8-biased spectrum of cytokines from human PBMCs (predominantly TNF-α, IFN-γ, IL-12).3