Oct3/4 Isoform A Antibody, anti-human/mouse, Vio® R667, REAfinity™

01MT11263

Clone REA338 recognizes the human octamer-binding transcription factor 3/4 isoform A (Oct3/4A) and the mouse Oct3/4. Oct3/4 is a homeodomain transcription factor belonging to the POU transcription factor family and is also known as POU domain class 5 transcription factor 1 (POU5F1). Oct3/4 is critical for the maintenance of totipotency in primate blastomeres and for pluripotency of the inner cell mass of developing mammalian embryos. This critical role of Oct3/4 is maintained in embryonic stem cells, the developing germline, and germline tumors, such as seminomas and embryonic teratocarcinomas