O4 Antibody, anti-human/mouse/rat, APC, REAfinity™

01MT11447

Clone REA576 recognizes the human, mouse, and rat O4 antigen, a marker for oligodendrocytes, which are a type of glial cells. Their function is to provide a supporting role for neurons. During oligodendrocyte development, late A2B5+ oligodendrocyte progenitors start to express O4. As the cells differentiate, A2B5 expression ceases, whereas O4 expression persists. More mature cells start to synthesize galactocerebroside, MBP, PLP, MOG, and O1. O4 expression is found on Schwann cells in the peripheral nervous system.Additional information: Clone REA576 displays negligible binding to Fc receptors