Notch1 Antibody, anti-human/mouse, APC, REAfinity™

01MT03236

Clone REA357 recognizes the human and mouse neurogenic locus notch homolog protein 1 (notch1) antigen, a 300 kDa single-pass type I membrane protein also known as translocation-associated notch protein (TAN-1). Following cleavage in the Golgi, notch forms a heterodimer composed of a 180–200 kDa disulfide-linked extracellular domain (NEXT), and a 120 kDa membrane-bound intracellular portion (NICD). Upon ligand binding the latter is cleaved to form the notch intracellular domain transcription factor. Notch signaling controls cell fate decisions and is involved in multiple cellular differentiatio