Lck pY505 Antibody, anti-human, APC, REAfinity™

01MT05425

Clone REA673 recognizes the human Lck antigen, phosphorylated at tyrosine 505. Lck is a non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T cells in the thymus and in the function of mature T cells. It is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature α/β TCR. Lck plays a key role in the T cell antigen receptor (TCR)–linked signal transduction pathways and is constitutively associated with the cytoplasmic portions of the CD4 and CD