IL-36α/Il36a/IL-1F6, Mouse, Recombinant

05PR00012

产品信息 产品形态 粉末 产品规格 10μg / 50μg / 500μg / 1mg 别名 Interleukin-36 alpha;Il36a;FIL1 epsilon;Interleukin-1 epsilon;IL-1 epsilon;nterleukin-1 family member 6;IL-1F6;Interleukin-1 homolog 1;IL-1H1;Fil1e;Il1e;Il1f6;Il1h1 物种 小鼠 表达宿主 E.coli 序列信息 Arg8-His160 检索号 Q9JLA2 分子量 17.3 kDa 表观分子量 16 kDa 纯度 > 95% as determined by reducing SDS-PAGE. 内毒素 < 0.1 EU/μg 储存条件 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. 运输条件 Ambient temperature or ice pack. 有效期 12个月 制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. 复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in sterile water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 体系描述 GMP生产和质量体系 公司符合cGMP的要求，已通过NMPA的第一类医疗器械生产备案，且通过ISO 13485和ISO 9001标准认证。公司生产的IL-36α/Il36a/IL-1F6, Mouse, Recombinant符合ISO 9001的cGMP标准。 背景介绍 Interleukin-36 alpha (Il-36a) is a member of the IL-1 family. IL-1α, IL-1β and IL-18 are potent inflammatory Cytokines whose activities are dependent on heterodimeric Receptors of the IL-1R superfamily, and which are regulated by soluble antagonists. Il36a is a Cytokine that binds to and signals through the IL1RL2/IL-36R Receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. It is a part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coReceptor IL1RAP. It seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. It Induces the production of proinflammatory Cytokines, including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23 in bone marrow-Derived dendritic cells (BMDCs). Moreover, it is involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II and can induce the production of IFN-gamma, IL-4 and IL-17 by cultured CD4+ T cells and splenocytes. Il36a may play a role in proinflammatory effects in the lung: induces the expression of CXCL1 and CXCL2 in the lung, and the expression of TNF-alpha, IL-36c, IL-1A, IL-1B, CXCL1 and CXCL2 in isolated splenic CD11c+ alveolar macrophages. It may be involved in T cell maturation by stimulating the surface expression of CD40 and modestly CD80 and CD86 in splenic CD11c+ cells and CD4+ T cell proliferation.