IL-31 Antibody, anti-human, PE, REAfinity™

01MT13599

Clone REA1363 recognizes the human IL-31 protein, which is a member of the gp130/IL-6 cytokine family. Human IL-31 is a cytokine that plays a role in inflammation of the skin. It is preferentially produced by type 2 helper T cells. IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL31RA) and oncostatin M receptor subunits ((OSMRβ). These receptor subunits are expressed in activated monocytes and in unstimulated epithelial cells. Signaling also involves the JAK/STAT pathway, the PI3 kinase/AKT cascade, and the MAP kinase pathway. Additional information: Clone REA1363