IL-12 (p70) Antibody, anti-human, PE, REAfinity™

01MT05052

Interleukin-12 (IL-12) is a 70–75 kDa heterodimeric cytokine composed of a 40 kDa heavy chain and a 35 kDa light chain. It is produced mainly by monocytes and macrophages and by dendritic cells, primarily in response to stimulation with bacterial or viral antigens. IL-12 has also been described to be produced by non-hematopoietic cells such as keratinocytes and epidermoid carcinomas. IL-12 displays various effects on both NK and T cells, playing an essential role in the interaction between innate and adaptive immunity. It induces the production of IFN-γ alone or in synergy with IL-2, acts as a