IgM Antibody, anti-human, PE, REAfinity™

01MT14035

REA1457 recognizes IgM, the first immunoglobulin produced by B cells in the immune response. Surface IgM is expressed on immature and mature B cells, whereas IgM heavy chain is expressed intracellularly in pre-B cells. IgM serves as the antigen receptor of naive B cells and is involved in B cell maturation and complement activation. It reacts with the soluble as well as membrane-bound form of human IgM. In immunohistochemical analyses targeting markers associated with antibody production, differential staining intensities are commonly observed between plasma cells and B lymphocytes. Plasma cel