人 ZNRF1 抗体对
01AB01877
Zinc and ring finger 1 (ZNRF1) is a membrane-associated RING-type E3 ubiquitin ligase primarily expressed in the nervous system, where it regulates neuronal signaling and axonal integrity. It contains a C3HC4 RING zinc finger domain that facilitates interaction with ubiquitin-conjugating (E2) enzymes to promote the transfer of ubiquitin to substrate proteins for proteasomal degradation. ZNRF1 is a key mediator of injury-induced axon degeneration, acting through the ubiquitination of signaling components involved in Wallerian-like processes. While its upregulation is known to accelerate axonal loss in experimental models of neurodegeneration and neuropathic injury, its role in human disease is currently characterized as modulatory.
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技术参数
- 靶点基因名
- ZNRF1
- 基因别名
- NIN283
- 蛋白别名
- zinc and ring finger 1; ZNRF1
- UniProt
- Q8ND25
- 物种
- Human
产品详情
- 靶点名称
- ZNRF1
- 蛋白名称
- zinc and ring finger 1
- 蛋白别名
- E3 ubiquitin-protein ligase ZNRF1; Nerve injury-induced gene 283 protein; RING-type E3 ubiquitin transferase ZNRF1; Zinc/RING finger protein 1
- 靶点基因名
- ZNRF1
- 基因别名
- NIN283
- UniProt
- Q8ND25
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Zinc and ring finger 1 (ZNRF1) is a membrane-associated RING-type E3 ubiquitin ligase primarily expressed in the nervous system, where it regulates neuronal signaling and axonal integrity. It contains a C3HC4 RING zinc finger domain that facilitates interaction with ubiquitin-conjugating (E2) enzymes to promote the transfer of ubiquitin to substrate proteins for proteasomal degradation. ZNRF1 is a key mediator of injury-induced axon degeneration, acting through the ubiquitination of signaling components involved in Wallerian-like processes. While its upregulation is known to accelerate axonal loss in experimental models of neurodegeneration and neuropathic injury, its role in human disease is currently characterized as modulatory.