抗人 ZBTB17 抗体对
01AB03825
Zinc finger and BTB domain-containing protein 17 (ZBTB17), also known as Miz-1, is a transcription factor characterized by its BTB/POZ domain and multiple zinc finger motifs, which facilitate its role in DNA binding and protein-protein interactions. ZBTB17 is involved in regulating gene expression during various biological processes, including lymphocyte development and cell cycle progression. It plays a crucial role in T cell differentiation by modulating IL-7 signaling and influencing the expression of genes associated with lymphopoiesis. Dysregulation of ZBTB17 has been linked to several diseases, particularly immune disorders and cancers. For instance, mutations or altered expression of ZBTB17 can lead to impaired T cell development, contributing to autoimmune diseases. Additionally, its role in regulating oncogenes suggests that ZBTB17 may act as a tumor suppressor; thus, its loss of function is associated with the progression of certain malignancies.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- ZBTB17
- 基因别名
- MIZ1; ZNF151; ZNF60
- 蛋白别名
- zinc finger and BTB domain containing 17; ZBTB17
- UniProt
- Q13105
- 物种
- Human
产品详情
- 靶点名称
- ZBTB17
- 蛋白名称
- zinc finger and BTB domain containing 17
- 蛋白别名
- Zinc finger and BTB domain-containing protein 17; Myc-interacting zinc finger protein 1; Miz-1; Zinc finger protein 151; Zinc finger protein 60
- 靶点基因名
- ZBTB17
- 基因别名
- MIZ1; ZNF151; ZNF60
- UniProt
- Q13105
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Zinc finger and BTB domain-containing protein 17 (ZBTB17), also known as Miz-1, is a transcription factor characterized by its BTB/POZ domain and multiple zinc finger motifs, which facilitate its role in DNA binding and protein-protein interactions. ZBTB17 is involved in regulating gene expression during various biological processes, including lymphocyte development and cell cycle progression. It plays a crucial role in T cell differentiation by modulating IL-7 signaling and influencing the expression of genes associated with lymphopoiesis. Dysregulation of ZBTB17 has been linked to several diseases, particularly immune disorders and cancers. For instance, mutations or altered expression of ZBTB17 can lead to impaired T cell development, contributing to autoimmune diseases. Additionally, its role in regulating oncogenes suggests that ZBTB17 may act as a tumor suppressor; thus, its loss of function is associated with the progression of certain malignancies.