抗人 ZBTB16 抗体对
01AB00994
Zinc finger and BTB domain containing 16 (ZBTB16), also known as PLZF, is a nuclear transcription factor characterized by nine Kruppel-type C2H2 zinc finger domains at its carboxyl terminus and a BTB/POZ domain, placing it within the Krueppel C2H2-type zinc-finger protein family. ZBTB16 functions primarily as a transcriptional regulator, modulating gene expression through interactions with histone deacetylases and acting as a chromatin remodeler in a context-dependent manner. It plays crucial roles in cell cycle progression, neural progenitor cell proliferation, neuronal differentiation, and the development and function of innate-like unconventional T cells, including invariant natural killer T (iNKT) and gamma-delta T cells. Disease associations include its involvement in acute promyelocytic leukemia (APL) due to aberrant gene rearrangements, and its dysregulation has been linked to neurodevelopmental disorders such as autism spectrum disorder and schizophrenia, as well as cognitive and behavioral impairments in animal models.
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技术参数
- 靶点基因名
- ZBTB16
- 基因别名
- PLZF; ZNF145
- 蛋白别名
- zinc finger and BTB domain containing 16; ZBTB16
- UniProt
- Q05516
- 物种
- Human
产品详情
- 靶点名称
- ZBTB16
- 蛋白名称
- zinc finger and BTB domain containing 16
- 蛋白别名
- Zinc finger and BTB domain-containing protein 16; Promyelocytic leukemia zinc finger protein; Zinc finger protein 145; Zinc finger protein PLZF
- 靶点基因名
- ZBTB16
- 基因别名
- PLZF; ZNF145
- UniProt
- Q05516
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Zinc finger and BTB domain containing 16 (ZBTB16), also known as PLZF, is a nuclear transcription factor characterized by nine Kruppel-type C2H2 zinc finger domains at its carboxyl terminus and a BTB/POZ domain, placing it within the Krueppel C2H2-type zinc-finger protein family. ZBTB16 functions primarily as a transcriptional regulator, modulating gene expression through interactions with histone deacetylases and acting as a chromatin remodeler in a context-dependent manner. It plays crucial roles in cell cycle progression, neural progenitor cell proliferation, neuronal differentiation, and the development and function of innate-like unconventional T cells, including invariant natural killer T (iNKT) and gamma-delta T cells. Disease associations include its involvement in acute promyelocytic leukemia (APL) due to aberrant gene rearrangements, and its dysregulation has been linked to neurodevelopmental disorders such as autism spectrum disorder and schizophrenia, as well as cognitive and behavioral impairments in animal models.