抗人 YY1 抗体对
01AB00992
YY1 transcription factor (YY1) is a ubiquitously expressed 414 amino acid transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. First described in 1991, YY1 functions as both a transcriptional activator and repressor, with activation domains near the N-terminus and repression domains overlapping the C-terminal zinc fingers. YY1 regulates gene expression through multiple mechanisms: as a DNA-binding transcription factor interacting with various cofactors, by recruiting histone-modifying enzymes (deacetylases and acetyltransferases), through interaction with chromatin remodeling complexes, and by promoting enhancer-promoter chromatin loops through dimer formation. YY1 catalyzes H3K27Me3 histone methylation, suppressing tumor suppressor genes. Clinically, heterozygous deletions and mutations in YY1 cause Gabriele-DeVries syndrome (GADEVS), an autosomal dominant neurodevelopmental disorder characterized by intellectual disability, dysmorphic facial features, feeding problems, intrauterine growth restriction, variable cognitive impairment, behavioral problems, and other congenital malformations.
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技术参数
- 靶点基因名
- YY1
- 基因别名
- INO80S
- 蛋白别名
- YY1 transcription factor; YY1
- UniProt
- P25490
- 物种
- Human
产品详情
- 靶点名称
- YY1
- 蛋白名称
- YY1 transcription factor
- 蛋白别名
- Transcriptional repressor protein YY1; Delta transcription factor; INO80 complex subunit S; NF-E1; Yin and yang 1; YY-1
- 靶点基因名
- YY1
- 基因别名
- INO80S
- UniProt
- P25490
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
YY1 transcription factor (YY1) is a ubiquitously expressed 414 amino acid transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. First described in 1991, YY1 functions as both a transcriptional activator and repressor, with activation domains near the N-terminus and repression domains overlapping the C-terminal zinc fingers. YY1 regulates gene expression through multiple mechanisms: as a DNA-binding transcription factor interacting with various cofactors, by recruiting histone-modifying enzymes (deacetylases and acetyltransferases), through interaction with chromatin remodeling complexes, and by promoting enhancer-promoter chromatin loops through dimer formation. YY1 catalyzes H3K27Me3 histone methylation, suppressing tumor suppressor genes. Clinically, heterozygous deletions and mutations in YY1 cause Gabriele-DeVries syndrome (GADEVS), an autosomal dominant neurodevelopmental disorder characterized by intellectual disability, dysmorphic facial features, feeding problems, intrauterine growth restriction, variable cognitive impairment, behavioral problems, and other congenital malformations.