抗人 YQ015 抗体对
01AB02769
YQ015 is a recombinant human protein expressed in E. coli or 293F systems, likely related to de novo designed self-assembling peptides like the Y15 variant, which forms amphiphilic β-sheet nanofibers through hydrophobic Tyr interactions, π–π stacking, electrostatic Glu-Lys bonds, and hydrogen bonding on the main chain . This peptide exhibits strong assembly propensity in aqueous solutions and cellular contexts, with critical aggregation concentrations around 50 nM for Y15-tagged superfolder green fluorescent protein (sfGFP), forming irreversible solid-like fibrous structures less sensitive to ionic strength up to 500 mM NaCl; its hydrophobic interfaces remain dry, distinguishing it from hydrophilic liquid-liquid phase separation motifs like FUS LC domains . These properties enable bottom-up synthesis of intracellular supramolecules and guide-tag systems for client protein enrichment.
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技术参数
- 蛋白别名
- Putative uncharacterized protein FLJ43944; YQ015
- UniProt
- Q6ZRG5
- 物种
- Human
产品详情
- 靶点名称
- YQ015
- 蛋白名称
- Putative uncharacterized protein FLJ43944
- 蛋白别名
- Putative uncharacterized protein FLJ43944
- 靶点基因名
- TBD
- UniProt
- Q6ZRG5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
YQ015 is a recombinant human protein expressed in E. coli or 293F systems, likely related to de novo designed self-assembling peptides like the Y15 variant, which forms amphiphilic β-sheet nanofibers through hydrophobic Tyr interactions, π–π stacking, electrostatic Glu-Lys bonds, and hydrogen bonding on the main chain . This peptide exhibits strong assembly propensity in aqueous solutions and cellular contexts, with critical aggregation concentrations around 50 nM for Y15-tagged superfolder green fluorescent protein (sfGFP), forming irreversible solid-like fibrous structures less sensitive to ionic strength up to 500 mM NaCl; its hydrophobic interfaces remain dry, distinguishing it from hydrophilic liquid-liquid phase separation motifs like FUS LC domains . These properties enable bottom-up synthesis of intracellular supramolecules and guide-tag systems for client protein enrichment.