人 YOD1 抗体对
01AB03482
YOD1 deubiquitinase (YOD1) is a cysteine protease belonging to the ovarian tumor (OTU) domain subfamily that plays a critical role in protein quality control. It hydrolyzes a wide range of polyubiquitin linkages, including K11, K27, K29, K33, and K48 chains, to facilitate the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. By trimming ubiquitin chains, YOD1 enables substrate threading through the VCP/p97 pore for proteasomal degradation. Additionally, YOD1 supports macroautophagy by recruiting PLAA, UBXN6, and VCP to damaged lysosomes marked with K48-linked ubiquitin, thereby facilitating chain removal and subsequent autophagosome formation. Its enzymatic activity is essential for maintaining cellular homeostasis by managing protein turnover and organelle integrity.
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技术参数
- 靶点基因名
- YOD1
- 基因别名
- DUBA8; HIN7; OTUD2
- 蛋白别名
- YOD1 deubiquitinase; YOD1
- UniProt
- Q5VVQ6
- 物种
- Human
产品详情
- 靶点名称
- YOD1
- 蛋白名称
- YOD1 deubiquitinase
- 蛋白别名
- Ubiquitin thioesterase OTU1; DUBA-8; HIV-1-induced protease 7; HIN-7; HsHIN7; OTU domain-containing protein 2
- 靶点基因名
- YOD1
- 基因别名
- DUBA8; HIN7; OTUD2
- UniProt
- Q5VVQ6
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
YOD1 deubiquitinase (YOD1) is a cysteine protease belonging to the ovarian tumor (OTU) domain subfamily that plays a critical role in protein quality control. It hydrolyzes a wide range of polyubiquitin linkages, including K11, K27, K29, K33, and K48 chains, to facilitate the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. By trimming ubiquitin chains, YOD1 enables substrate threading through the VCP/p97 pore for proteasomal degradation. Additionally, YOD1 supports macroautophagy by recruiting PLAA, UBXN6, and VCP to damaged lysosomes marked with K48-linked ubiquitin, thereby facilitating chain removal and subsequent autophagosome formation. Its enzymatic activity is essential for maintaining cellular homeostasis by managing protein turnover and organelle integrity.