人 XBP1 抗体对
01AB01873
X-box binding protein 1 (XBP1) is a basic leucine zipper transcription factor that serves as a master regulator of the unfolded protein response (UPR) and endoplasmic reticulum (ER) stress. Upon ER stress, XBP1 mRNA undergoes unconventional splicing by IRE1 to produce the active XBP1s isoform, which upregulates ER chaperones, components of ER-associated degradation, and phospholipid biosynthesis to restore proteostasis. Beyond its role in the UPR, XBP1 is essential for plasma cell differentiation, immunoglobulin production, and the development of secretory tissues. Clinically, dysregulated XBP1 signaling is a hallmark of multiple myeloma survival and is implicated in atherosclerosis, neurodegenerative diseases, and metabolic disorders. In cancer, persistent XBP1 activation promotes tumor growth, angiogenesis, and resistance to therapy.
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技术参数
- 靶点基因名
- XBP1
- 基因别名
- TREB5; XBP2
- 蛋白别名
- X-box binding protein 1; XBP1
- UniProt
- P17861
- 物种
- Human
产品详情
- 靶点名称
- XBP1
- 蛋白名称
- X-box binding protein 1
- 蛋白别名
- X-box-binding protein 1; XBP-1; Tax-responsive element-binding protein 5; TREB-5) [Cleaved into: X-box-binding protein 1; cytoplasmic form; X-box-binding protein 1; luminal form]
- 靶点基因名
- XBP1
- 基因别名
- TREB5; XBP2
- UniProt
- P17861
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
X-box binding protein 1 (XBP1) is a basic leucine zipper transcription factor that serves as a master regulator of the unfolded protein response (UPR) and endoplasmic reticulum (ER) stress. Upon ER stress, XBP1 mRNA undergoes unconventional splicing by IRE1 to produce the active XBP1s isoform, which upregulates ER chaperones, components of ER-associated degradation, and phospholipid biosynthesis to restore proteostasis. Beyond its role in the UPR, XBP1 is essential for plasma cell differentiation, immunoglobulin production, and the development of secretory tissues. Clinically, dysregulated XBP1 signaling is a hallmark of multiple myeloma survival and is implicated in atherosclerosis, neurodegenerative diseases, and metabolic disorders. In cancer, persistent XBP1 activation promotes tumor growth, angiogenesis, and resistance to therapy.