人 WWP1 抗体对
01AB04169
NEDD4-like E3 ubiquitin-protein ligase WWP1 (WWP1) is a member of the HECT (Homologous to the E6-AP Carboxyl Terminus) family of E3 ubiquitin ligases, characterized by an N-terminal C2 domain, four WW domains, and a C-terminal HECT domain. This protein plays a crucial role in regulating various cellular processes, including protein degradation, signal transduction, and cellular proliferation through ubiquitination of target proteins. Dysregulation of WWP1 has been implicated in several diseases, particularly cancers such as breast, prostate, and colorectal cancer, where it can function as an oncogene by promoting tumor growth and survival. Additionally, mutations in WWP1 are associated with Cowden syndrome and Cowden-like syndrome, which increase the risk of developing multiple tumors due to impaired PTEN tumor suppressor activity.
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技术参数
- 靶点基因名
- WWP1
- 蛋白别名
- WW domain containing E3 ubiquitin protein ligase 1; WWP1
- UniProt
- Q9H0M0
- 物种
- Human
产品详情
- 靶点名称
- WWP1
- 蛋白名称
- WW domain containing E3 ubiquitin protein ligase 1
- 蛋白别名
- NEDD4-like E3 ubiquitin-protein ligase WWP1; Atrophin-1-interacting protein 5; AIP5; HECT-type E3 ubiquitin transferase WWP1; TGIF-interacting ubiquitin ligase 1; Tiul1; WW domain-containing protein 1
- 靶点基因名
- WWP1
- UniProt
- Q9H0M0
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
NEDD4-like E3 ubiquitin-protein ligase WWP1 (WWP1) is a member of the HECT (Homologous to the E6-AP Carboxyl Terminus) family of E3 ubiquitin ligases, characterized by an N-terminal C2 domain, four WW domains, and a C-terminal HECT domain. This protein plays a crucial role in regulating various cellular processes, including protein degradation, signal transduction, and cellular proliferation through ubiquitination of target proteins. Dysregulation of WWP1 has been implicated in several diseases, particularly cancers such as breast, prostate, and colorectal cancer, where it can function as an oncogene by promoting tumor growth and survival. Additionally, mutations in WWP1 are associated with Cowden syndrome and Cowden-like syndrome, which increase the risk of developing multiple tumors due to impaired PTEN tumor suppressor activity.