人 WWC1 抗体对
01AB03035
WW and C2 domain containing 1 (WWC1), also known as KIBRA, is a cytoplasmic scaffolding protein that integrates multiple signaling pathways via its WW, C2, and PDZ-binding domains. It acts as a critical regulator of the Hippo signaling pathway by promoting LATS kinase activity and suppressing YAP-dependent transcription, thereby controlling cell proliferation and organ size. In the nervous system, WWC1 modulates synaptic plasticity and AMPA receptor trafficking, processes underlying learning and memory. Genetic variations in WWC1 are associated with human memory performance and cognitive traits. Furthermore, its involvement in dendritic spinogenesis and protein trafficking links it to neurodegenerative conditions, including Alzheimer’s disease.
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技术参数
- 靶点基因名
- WWC1
- 基因别名
- KIAA0869; KIBRA
- 蛋白别名
- WW and C2 domain containing 1; WWC1
- UniProt
- Q8IX03
- 物种
- Human
产品详情
- 靶点名称
- WWC1
- 蛋白名称
- WW and C2 domain containing 1
- 蛋白别名
- Protein KIBRA; HBeAg-binding protein 3; Kidney and brain protein; KIBRA; WW domain-containing protein 1
- 靶点基因名
- WWC1
- 基因别名
- KIAA0869; KIBRA
- UniProt
- Q8IX03
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
WW and C2 domain containing 1 (WWC1), also known as KIBRA, is a cytoplasmic scaffolding protein that integrates multiple signaling pathways via its WW, C2, and PDZ-binding domains. It acts as a critical regulator of the Hippo signaling pathway by promoting LATS kinase activity and suppressing YAP-dependent transcription, thereby controlling cell proliferation and organ size. In the nervous system, WWC1 modulates synaptic plasticity and AMPA receptor trafficking, processes underlying learning and memory. Genetic variations in WWC1 are associated with human memory performance and cognitive traits. Furthermore, its involvement in dendritic spinogenesis and protein trafficking links it to neurodegenerative conditions, including Alzheimer’s disease.