人 WDR70 抗体对
01AB02559
WD repeat domain 70 (WDR70) is a nuclear scaffolding protein characterized by multiple WD40 repeats that form a beta-propeller structure. It functions as a critical subunit of the CRL4 ubiquitin ligase complex, where it coordinates the DNA damage response and maintains genomic stability. WDR70 localizes to sites of DNA double-strand breaks and regulates the transcription of essential repair genes, including BRCA1, BRCA2, and RAD51, thereby promoting both homologous recombination and non-homologous end joining. Furthermore, it interacts with the RNF20/40 E3 ligase to enhance histone H2BK120 monoubiquitylation, which facilitates downstream H3K79 methylation and the expression of POLE3. Through these mechanisms, WDR70 acts as a central regulator of chromatin modifications and DNA repair pathways.
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技术参数
- 靶点基因名
- WDR70
- 蛋白别名
- WD repeat domain 70; WDR70
- UniProt
- Q9NW82
- 物种
- Human
产品详情
- 靶点名称
- WDR70
- 蛋白名称
- WD repeat domain 70
- 蛋白别名
- WD repeat-containing protein 70
- 靶点基因名
- WDR70
- UniProt
- Q9NW82
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
WD repeat domain 70 (WDR70) is a nuclear scaffolding protein characterized by multiple WD40 repeats that form a beta-propeller structure. It functions as a critical subunit of the CRL4 ubiquitin ligase complex, where it coordinates the DNA damage response and maintains genomic stability. WDR70 localizes to sites of DNA double-strand breaks and regulates the transcription of essential repair genes, including BRCA1, BRCA2, and RAD51, thereby promoting both homologous recombination and non-homologous end joining. Furthermore, it interacts with the RNF20/40 E3 ligase to enhance histone H2BK120 monoubiquitylation, which facilitates downstream H3K79 methylation and the expression of POLE3. Through these mechanisms, WDR70 acts as a central regulator of chromatin modifications and DNA repair pathways.