人 WDR26 抗体对
01AB02708
WD repeat domain 26 (WDR26) is a scaffolding protein characterized by multiple WD repeats that form a beta-propeller structure, facilitating the assembly of diverse protein complexes. It plays a multifaceted role in cellular signaling, acting as a G-beta-like scaffold that promotes the activation of PLCB2 in leukocytes and negatively regulates the MAPK and canonical Wnt signaling pathways by stabilizing beta-catenin. Additionally, WDR26 serves as a core component of the CTLH E3 ubiquitin ligase complex, targeting substrates such as HBP1 for degradation. It also coordinates PI3K/AKT-driven growth and protects cells against oxidative stress through the inhibition of AP-1 and the promotion of autophagy. Clinically, WDR26 is well-established as the causative gene for Skraban-Deardorff syndrome, a neurodevelopmental disorder characterized by intellectual disability, hypotonia, and craniofacial dysmorphism. It has also been identified as a risk factor in autism spectrum disorders, highlighting its critical role in neural development and cellular homeostasis.
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技术参数
- 靶点基因名
- WDR26
- 基因别名
- CDW2; MIP2
- 蛋白别名
- WD repeat domain 26; WDR26
- UniProt
- Q9H7D7
- 物种
- Human
产品详情
- 靶点名称
- WDR26
- 蛋白名称
- WD repeat domain 26
- 蛋白别名
- WD repeat-containing protein 26; CUL4- and DDB1-associated WDR protein 2; Myocardial ischemic preconditioning up-regulated protein 2
- 靶点基因名
- WDR26
- 基因别名
- CDW2; MIP2
- UniProt
- Q9H7D7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
WD repeat domain 26 (WDR26) is a scaffolding protein characterized by multiple WD repeats that form a beta-propeller structure, facilitating the assembly of diverse protein complexes. It plays a multifaceted role in cellular signaling, acting as a G-beta-like scaffold that promotes the activation of PLCB2 in leukocytes and negatively regulates the MAPK and canonical Wnt signaling pathways by stabilizing beta-catenin. Additionally, WDR26 serves as a core component of the CTLH E3 ubiquitin ligase complex, targeting substrates such as HBP1 for degradation. It also coordinates PI3K/AKT-driven growth and protects cells against oxidative stress through the inhibition of AP-1 and the promotion of autophagy. Clinically, WDR26 is well-established as the causative gene for Skraban-Deardorff syndrome, a neurodevelopmental disorder characterized by intellectual disability, hypotonia, and craniofacial dysmorphism. It has also been identified as a risk factor in autism spectrum disorders, highlighting its critical role in neural development and cellular homeostasis.