抗人 WAVE-2 抗体对
01AB00987
WASP family member 2 (WASF2), also known as WAVE2, is a cytoskeletal regulatory protein that belongs to the Wiskott-Aldrich syndrome protein family. It functions as a downstream effector transmitting signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton, facilitating actin polymerization through its conserved C-terminal verprolin homology (WH2) domain. WASF2 forms part of a multiprotein complex that links receptor kinases to actin, playing a key role in actin cytoskeleton reorganization, cell motility, and membrane dynamics. It is involved in processes such as lamellipodia formation and T cell receptor signaling, with dynamic regulation by phosphorylation and interactions with proteins like Pak1. WASF2 is widely expressed in various tissues, including the brain, immune cells, and muscle. Dysregulation of WASF2 has been implicated in cancer progression, metastasis, and immune dysfunctions, as it influences cell migration and invasion. Its aberrant activity contributes to tumor cell invasiveness and may affect immune cell function.
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技术参数
- 靶点基因名
- WASF2
- 基因别名
- WAVE2
- 蛋白别名
- WASP family member 2; WAVE-2
- UniProt
- Q9Y6W5
- 物种
- Human
产品详情
- 靶点名称
- WAVE-2
- 蛋白名称
- WASP family member 2
- 蛋白别名
- Actin-binding protein WASF2; Protein WAVE-2; Verprolin homology domain-containing protein 2; Wiskott-Aldrich syndrome protein family member 2; WASP family protein member 2
- 靶点基因名
- WASF2
- 基因别名
- WAVE2
- UniProt
- Q9Y6W5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
WASP family member 2 (WASF2), also known as WAVE2, is a cytoskeletal regulatory protein that belongs to the Wiskott-Aldrich syndrome protein family. It functions as a downstream effector transmitting signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton, facilitating actin polymerization through its conserved C-terminal verprolin homology (WH2) domain. WASF2 forms part of a multiprotein complex that links receptor kinases to actin, playing a key role in actin cytoskeleton reorganization, cell motility, and membrane dynamics. It is involved in processes such as lamellipodia formation and T cell receptor signaling, with dynamic regulation by phosphorylation and interactions with proteins like Pak1. WASF2 is widely expressed in various tissues, including the brain, immune cells, and muscle. Dysregulation of WASF2 has been implicated in cancer progression, metastasis, and immune dysfunctions, as it influences cell migration and invasion. Its aberrant activity contributes to tumor cell invasiveness and may affect immune cell function.