抗人 VWC2L 抗体对
01AB02358
Von Willebrand factor C domain containing 2 like (VWC2L) is a secreted, cysteine-rich glycoprotein characterized by von Willebrand factor C (VWC) domains. It localizes to the extracellular region, synapses, and the AMPA glutamate receptor complex, where it functions as a modulator of developmental signaling pathways. VWC2L negatively regulates bone morphogenetic protein (BMP) signaling and influences the TGF-beta superfamily to promote bone differentiation and matrix mineralization through the osteoblast transcription factor Osterix. Additionally, it is predicted to facilitate neuron differentiation and neurogenesis. Clinically, VWC2L is associated with skeletal disorders such as tarsal-carpal coalition syndrome and sclerosteosis 1, highlighting its critical role in bone patterning and the maintenance of bone mass.
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技术参数
- 靶点基因名
- VWC2L
- 蛋白别名
- von Willebrand factor C domain containing 2 like; VWC2L
- UniProt
- B2RUY7
- 物种
- Human
产品详情
- 靶点名称
- VWC2L
- 蛋白名称
- von Willebrand factor C domain containing 2 like
- 蛋白别名
- von Willebrand factor C domain-containing protein 2-like; VWC2-like protein; Brorin-like
- 靶点基因名
- VWC2L
- UniProt
- B2RUY7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Von Willebrand factor C domain containing 2 like (VWC2L) is a secreted, cysteine-rich glycoprotein characterized by von Willebrand factor C (VWC) domains. It localizes to the extracellular region, synapses, and the AMPA glutamate receptor complex, where it functions as a modulator of developmental signaling pathways. VWC2L negatively regulates bone morphogenetic protein (BMP) signaling and influences the TGF-beta superfamily to promote bone differentiation and matrix mineralization through the osteoblast transcription factor Osterix. Additionally, it is predicted to facilitate neuron differentiation and neurogenesis. Clinically, VWC2L is associated with skeletal disorders such as tarsal-carpal coalition syndrome and sclerosteosis 1, highlighting its critical role in bone patterning and the maintenance of bone mass.