人 VPS8 抗体对
01AB01418
VPS8 subunit of CORVET complex (VPS8) is a key subunit of the CORVET (class C core vacuole/endosome tethering) complex, which functions as a membrane tethering factor in the endolysosomal system, specifically at early and late endosomes. Structurally, VPS8 features an elbow-shaped configuration with long C-terminal α-helices and RING finger domains that anchor it firmly to the CORVET core, interacting primarily with Vps18 and Vps11 subunits. This anchoring not only stabilizes the complex but also facilitates the attachment of the SNARE-binding module, enhancing membrane fusion processes. VPS8 acts as an effector for Rab5 homologs, such as Vps21, mediating endosomal membrane clustering and tethering essential for vesicle trafficking and fusion. Functionally, VPS8’s interactions regulate endosome maturation and trafficking pathways critical for cellular homeostasis. Disruptions in CORVET function, including VPS8 mutations or misregulation, could impair endosomal trafficking and contribute to neurodegenerative diseases and disorders involving lysosomal dysfunction, given the complex’s central role in endolysosomal membrane dynamics and intracellular transport.
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技术参数
- 靶点基因名
- VPS8
- 基因别名
- KIAA0804
- 蛋白别名
- VPS8 subunit of CORVET complex; VPS8
- UniProt
- Q8N3P4
- 物种
- Human
产品详情
- 靶点名称
- VPS8
- 蛋白名称
- VPS8 subunit of CORVET complex
- 蛋白别名
- Vacuolar protein sorting-associated protein 8 homolog
- 靶点基因名
- VPS8
- 基因别名
- KIAA0804
- UniProt
- Q8N3P4
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
VPS8 subunit of CORVET complex (VPS8) is a key subunit of the CORVET (class C core vacuole/endosome tethering) complex, which functions as a membrane tethering factor in the endolysosomal system, specifically at early and late endosomes. Structurally, VPS8 features an elbow-shaped configuration with long C-terminal α-helices and RING finger domains that anchor it firmly to the CORVET core, interacting primarily with Vps18 and Vps11 subunits. This anchoring not only stabilizes the complex but also facilitates the attachment of the SNARE-binding module, enhancing membrane fusion processes. VPS8 acts as an effector for Rab5 homologs, such as Vps21, mediating endosomal membrane clustering and tethering essential for vesicle trafficking and fusion. Functionally, VPS8’s interactions regulate endosome maturation and trafficking pathways critical for cellular homeostasis. Disruptions in CORVET function, including VPS8 mutations or misregulation, could impair endosomal trafficking and contribute to neurodegenerative diseases and disorders involving lysosomal dysfunction, given the complex’s central role in endolysosomal membrane dynamics and intracellular transport.