人原聚糖蛋白核心蛋白抗体对
01AB00442
Versican (VCAN) is a large extracellular matrix proteoglycan that plays a critical role in cell adhesion, migration, and proliferation. It is encoded by the VCAN gene and exists in five isoforms (V0, V1, V2, V3, V4), which differ in their glycosaminoglycan (GAG) attachment domains. The core protein of versican contains globular domains at the amino and carboxyl termini, with the central domain decorated with chondroitin sulfate chains that contribute to its negative charge and various biological properties. Versican is involved in the development of various tissues, including the heart and nervous system, and its expression is often observed in pathological conditions such as cancer and autoimmune diseases. The cleavage of versican by ADAMTS enzymes produces fragments like versikine, which can act as damage-associated molecular patterns (DAMPs) and influence immune responses.
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技术参数
- 靶点基因名
- VCAN
- 基因别名
- CSPG2
- 蛋白别名
- versican; Versican Core Protein
- UniProt
- P13611
- 物种
- Human
产品详情
- 靶点名称
- Versican Core Protein
- 蛋白名称
- versican
- 蛋白别名
- Versican core protein; Chondroitin sulfate proteoglycan core protein 2; Chondroitin sulfate proteoglycan 2; Glial hyaluronate-binding protein; GHAP; Large fibroblast proteoglycan; PG-M
- 靶点基因名
- VCAN
- 基因别名
- CSPG2
- UniProt
- P13611
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Versican (VCAN) is a large extracellular matrix proteoglycan that plays a critical role in cell adhesion, migration, and proliferation. It is encoded by the VCAN gene and exists in five isoforms (V0, V1, V2, V3, V4), which differ in their glycosaminoglycan (GAG) attachment domains. The core protein of versican contains globular domains at the amino and carboxyl termini, with the central domain decorated with chondroitin sulfate chains that contribute to its negative charge and various biological properties. Versican is involved in the development of various tissues, including the heart and nervous system, and its expression is often observed in pathological conditions such as cancer and autoimmune diseases. The cleavage of versican by ADAMTS enzymes produces fragments like versikine, which can act as damage-associated molecular patterns (DAMPs) and influence immune responses.