人 VEGFD 抗体对
01AB03915
Vascular endothelial growth factor D (VEGFD) is a secreted protein that plays a crucial role in promoting the remodeling of blood vessels and lymphatics in development and disease. It is a member of the VEGF family of ligands and can activate both VEGFR-2 and VEGFR-3, which are cell surface receptor tyrosine kinases expressed on blood vessels and lymphatic vessels. VEGFD exists as a covalent-linked homodimer and can undergo extracellular proteolytic processing, which regulates its signaling properties. While VEGFD is dispensable for the development of the lymphatic system in mice, it can modulate lymphatics in the skin and enhance the density of lymphatics adjacent to bronchioles in the lung. VEGFD has been implicated in various diseases, including lymphangioleiomyomatosis, a rare lung disease characterized by abnormal smooth muscle cell proliferation.
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技术参数
- 靶点基因名
- VEGFD
- 基因别名
- FIGF
- 蛋白别名
- vascular endothelial growth factor D; VEGFD
- UniProt
- O43915
- 物种
- Human
产品详情
- 靶点名称
- VEGFD
- 蛋白名称
- vascular endothelial growth factor D
- 蛋白别名
- Vascular endothelial growth factor D; VEGF-D; c-Fos-induced growth factor; FIGF
- 靶点基因名
- VEGFD
- 基因别名
- FIGF
- UniProt
- O43915
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Vascular endothelial growth factor D (VEGFD) is a secreted protein that plays a crucial role in promoting the remodeling of blood vessels and lymphatics in development and disease. It is a member of the VEGF family of ligands and can activate both VEGFR-2 and VEGFR-3, which are cell surface receptor tyrosine kinases expressed on blood vessels and lymphatic vessels. VEGFD exists as a covalent-linked homodimer and can undergo extracellular proteolytic processing, which regulates its signaling properties. While VEGFD is dispensable for the development of the lymphatic system in mice, it can modulate lymphatics in the skin and enhance the density of lymphatics adjacent to bronchioles in the lung. VEGFD has been implicated in various diseases, including lymphangioleiomyomatosis, a rare lung disease characterized by abnormal smooth muscle cell proliferation.