人 VEGFB 抗体对
01AB01417
Vascular endothelial growth factor B (VEGFB) is a member of the VEGF family of signal proteins, primarily involved in the regulation of blood vessel formation (angiogenesis) and the development of lymphatic vessels. Structurally, VEGF proteins, including VEGFB, typically form homodimers stabilized by cystine-knot motifs and disulfide bonds, which are essential for their interaction with specific tyrosine kinase receptors such as VEGFR1 (Flt-1). These interactions trigger receptor dimerization and downstream signaling pathways, notably activating ERK1/2, which promotes endothelial cell proliferation and survival. VEGFB is particularly important in maintaining vascular integrity and supporting the blood supply to oxygen-deprived tissues. Dysregulation of VEGFB and its signaling pathways has been implicated in pathological conditions, including cardiovascular diseases and certain forms of cancer, where abnormal vessel growth or function contributes to disease progression.
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技术参数
- 靶点基因名
- VEGFB
- 基因别名
- VRF
- 蛋白别名
- vascular endothelial growth factor B; VEGFB
- UniProt
- P49765
- 物种
- Human
产品详情
- 靶点名称
- VEGFB
- 蛋白名称
- vascular endothelial growth factor B
- 蛋白别名
- Vascular endothelial growth factor B; VEGF-B; VEGF-related factor; VRF
- 靶点基因名
- VEGFB
- 基因别名
- VRF
- UniProt
- P49765
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Vascular endothelial growth factor B (VEGFB) is a member of the VEGF family of signal proteins, primarily involved in the regulation of blood vessel formation (angiogenesis) and the development of lymphatic vessels. Structurally, VEGF proteins, including VEGFB, typically form homodimers stabilized by cystine-knot motifs and disulfide bonds, which are essential for their interaction with specific tyrosine kinase receptors such as VEGFR1 (Flt-1). These interactions trigger receptor dimerization and downstream signaling pathways, notably activating ERK1/2, which promotes endothelial cell proliferation and survival. VEGFB is particularly important in maintaining vascular integrity and supporting the blood supply to oxygen-deprived tissues. Dysregulation of VEGFB and its signaling pathways has been implicated in pathological conditions, including cardiovascular diseases and certain forms of cancer, where abnormal vessel growth or function contributes to disease progression.