人 UVRAG 抗体对
01AB01869
UV radiation resistance associated (UVRAG) is a multifunctional protein characterized by domains including a proline-rich region, calcium-dependent C2 domain, coiled-coil domain, and DNA-PK binding domain. UVRAG plays essential roles in autophagy by activating the Beclin1-PI(3)KC3 complex, facilitating autophagosome formation and maturation, and regulating endocytic trafficking independently of Beclin1 through association with the class C Vps complex. It also maintains genomic stability by promoting DNA double-strand break repair via DNA-PK activation, ensuring proper chromosome segregation and centrosome stability. Disease associations include its tumor suppressor function, with mutations or under-expression linked to colorectal and bladder cancers, and chromosomal aberrations causing left-right axis malformations and increased UV sensitivity in xeroderma pigmentosum group C. UVRAG deficiency impairs DNA repair, increases UV-induced mutations, and predisposes to melanoma and other cancers, highlighting its significance in cellular homeostasis and disease prevention.
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技术参数
- 靶点基因名
- UVRAG
- 蛋白别名
- UV radiation resistance associated; UVRAG
- UniProt
- Q9P2Y5
- 物种
- Human
产品详情
- 靶点名称
- UVRAG
- 蛋白名称
- UV radiation resistance associated
- 蛋白别名
- UV radiation resistance-associated gene protein; p63
- 靶点基因名
- UVRAG
- UniProt
- Q9P2Y5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
UV radiation resistance associated (UVRAG) is a multifunctional protein characterized by domains including a proline-rich region, calcium-dependent C2 domain, coiled-coil domain, and DNA-PK binding domain. UVRAG plays essential roles in autophagy by activating the Beclin1-PI(3)KC3 complex, facilitating autophagosome formation and maturation, and regulating endocytic trafficking independently of Beclin1 through association with the class C Vps complex. It also maintains genomic stability by promoting DNA double-strand break repair via DNA-PK activation, ensuring proper chromosome segregation and centrosome stability. Disease associations include its tumor suppressor function, with mutations or under-expression linked to colorectal and bladder cancers, and chromosomal aberrations causing left-right axis malformations and increased UV sensitivity in xeroderma pigmentosum group C. UVRAG deficiency impairs DNA repair, increases UV-induced mutations, and predisposes to melanoma and other cancers, highlighting its significance in cellular homeostasis and disease prevention.