抗人 USP7 抗体对
01AB00982
Ubiquitin specific peptidase 7 (USP7) is a deubiquitinating enzyme that plays crucial roles in various cellular processes. It contains 1102 amino acids and consists of an N-terminal TRAF-like domain, a catalytic core domain, and five C-terminal ubiquitin-like domains. USP7 regulates protein stability by removing ubiquitin from target proteins, including p53, MDM2, and FOXO4. It is involved in DNA damage response, cell cycle regulation, and epigenetic modifications. USP7 also participates in immune signaling and maintenance of DNA methylation. Dysregulation of USP7 has been implicated in several diseases, particularly cancer. Aberrant expression and activity of USP7 are found in various cancers, contributing to tumor initiation and progression. Additionally, loss-of-function mutations in USP7 are associated with a neurodevelopmental disorder characterized by developmental delay, autism spectrum disorder, and epilepsy.
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技术参数
- 靶点基因名
- USP7
- 基因别名
- HAUSP
- 蛋白别名
- ubiquitin specific peptidase 7; USP7
- UniProt
- Q93009
- 物种
- Human
产品详情
- 靶点名称
- USP7
- 蛋白名称
- ubiquitin specific peptidase 7
- 蛋白别名
- Ubiquitin carboxyl-terminal hydrolase 7; Deubiquitinating enzyme 7; Herpesvirus-associated ubiquitin-specific protease; Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7
- 靶点基因名
- USP7
- 基因别名
- HAUSP
- UniProt
- Q93009
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ubiquitin specific peptidase 7 (USP7) is a deubiquitinating enzyme that plays crucial roles in various cellular processes. It contains 1102 amino acids and consists of an N-terminal TRAF-like domain, a catalytic core domain, and five C-terminal ubiquitin-like domains. USP7 regulates protein stability by removing ubiquitin from target proteins, including p53, MDM2, and FOXO4. It is involved in DNA damage response, cell cycle regulation, and epigenetic modifications. USP7 also participates in immune signaling and maintenance of DNA methylation. Dysregulation of USP7 has been implicated in several diseases, particularly cancer. Aberrant expression and activity of USP7 are found in various cancers, contributing to tumor initiation and progression. Additionally, loss-of-function mutations in USP7 are associated with a neurodevelopmental disorder characterized by developmental delay, autism spectrum disorder, and epilepsy.