抗人 USP6NL 抗体对
01AB00980
USP6 N-terminal like (USP6NL) is a protein that functions as a GTPase-activating protein for RAB5A and RAB43, playing a role in receptor trafficking and endocytosis. It is involved in various cellular processes, including plasma membrane to endosome transport, regulation of cilium assembly, and Golgi organization. USP6NL interacts with EPS8 to inhibit EGFR internalization and regulates actin dynamics. The protein is expressed in multiple tissues and has been implicated in several cancers. In glioblastoma multiforme, high levels of USP6NL are associated with therapy resistance, enhanced tumor growth, and invasion. USP6NL has been shown to delay EGFR endocytosis and degradation in breast cancer cells, leading to activated AKT signaling.
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技术参数
- 靶点基因名
- USP6NL
- 基因别名
- KIAA0019
- 蛋白别名
- USP6 N-terminal like; USP6NL
- UniProt
- Q92738
- 物种
- Human
产品详情
- 靶点名称
- USP6NL
- 蛋白名称
- USP6 N-terminal like
- 蛋白别名
- USP6 N-terminal-like protein; Related to the N-terminus of tre; RN-tre
- 靶点基因名
- USP6NL
- 基因别名
- KIAA0019
- UniProt
- Q92738
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
USP6 N-terminal like (USP6NL) is a protein that functions as a GTPase-activating protein for RAB5A and RAB43, playing a role in receptor trafficking and endocytosis. It is involved in various cellular processes, including plasma membrane to endosome transport, regulation of cilium assembly, and Golgi organization. USP6NL interacts with EPS8 to inhibit EGFR internalization and regulates actin dynamics. The protein is expressed in multiple tissues and has been implicated in several cancers. In glioblastoma multiforme, high levels of USP6NL are associated with therapy resistance, enhanced tumor growth, and invasion. USP6NL has been shown to delay EGFR endocytosis and degradation in breast cancer cells, leading to activated AKT signaling.