人 USP54 抗体对
01AB01411
Ubiquitin specific peptidase 54 (USP54) is a deubiquitinating enzyme belonging to the ubiquitin-specific protease family. It plays a crucial role in regulating protein stability and function by removing ubiquitin molecules from target proteins. USP54 is expressed in various tissues and is involved in maintaining stem cell properties. The enzyme's structure includes a catalytic domain responsible for its deubiquitinating activity. In terms of disease associations, USP54 has been implicated in cancer progression, particularly in colorectal cancer and prostate cancer. It is overexpressed in intestinal stem cells and colorectal cancer stem cells, promoting tumorigenesis. High levels of USP54 are associated with poor prognosis in colorectal carcinoma. Additionally, USP54 has been found to play a role in castration-resistant prostate cancer, where its upregulation contributes to disease progression.
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技术参数
- 靶点基因名
- USP54
- 基因别名
- C10orf29
- 蛋白别名
- ubiquitin specific peptidase 54; USP54
- UniProt
- Q70EL1
- 物种
- Human
产品详情
- 靶点名称
- USP54
- 蛋白名称
- ubiquitin specific peptidase 54
- 蛋白别名
- Inactive ubiquitin carboxyl-terminal hydrolase 54; Inactive ubiquitin-specific peptidase 54
- 靶点基因名
- USP54
- 基因别名
- C10orf29
- UniProt
- Q70EL1
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ubiquitin specific peptidase 54 (USP54) is a deubiquitinating enzyme belonging to the ubiquitin-specific protease family. It plays a crucial role in regulating protein stability and function by removing ubiquitin molecules from target proteins. USP54 is expressed in various tissues and is involved in maintaining stem cell properties. The enzyme's structure includes a catalytic domain responsible for its deubiquitinating activity. In terms of disease associations, USP54 has been implicated in cancer progression, particularly in colorectal cancer and prostate cancer. It is overexpressed in intestinal stem cells and colorectal cancer stem cells, promoting tumorigenesis. High levels of USP54 are associated with poor prognosis in colorectal carcinoma. Additionally, USP54 has been found to play a role in castration-resistant prostate cancer, where its upregulation contributes to disease progression.