人 Urokinase 抗体对
01AB01797
Plasminogen activator, urokinase (Urokinase) is a secreted serine protease that converts plasminogen into active plasmin, thereby initiating fibrinolysis and extracellular matrix degradation. Synthesized as a single-chain zymogen, it is activated by plasmin into a two-chain form that binds the GPI-anchored urokinase receptor (uPAR). This interaction localizes proteolytic activity to the cell surface, modulating cell adhesion and migration, particularly at the tumor-stroma interface. Urokinase is composed of a growth factor domain, a kringle domain, and a catalytic serine protease domain. Clinically, urokinase is an FDA-approved thrombolytic agent used for the treatment of pulmonary embolism and other acute thrombotic disorders, where it effectively promotes the dissolution of fibrin clots.
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技术参数
- 靶点基因名
- PLAU
- 蛋白别名
- plasminogen activator, urokinase; Urokinase
- UniProt
- P00749
- 物种
- Human
产品详情
- 靶点名称
- Urokinase
- 蛋白名称
- plasminogen activator, urokinase
- 蛋白别名
- Urokinase-type plasminogen activator; U-plasminogen activator; uPA) [Cleaved into: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B]
- 靶点基因名
- PLAU
- UniProt
- P00749
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Plasminogen activator, urokinase (Urokinase) is a secreted serine protease that converts plasminogen into active plasmin, thereby initiating fibrinolysis and extracellular matrix degradation. Synthesized as a single-chain zymogen, it is activated by plasmin into a two-chain form that binds the GPI-anchored urokinase receptor (uPAR). This interaction localizes proteolytic activity to the cell surface, modulating cell adhesion and migration, particularly at the tumor-stroma interface. Urokinase is composed of a growth factor domain, a kringle domain, and a catalytic serine protease domain. Clinically, urokinase is an FDA-approved thrombolytic agent used for the treatment of pulmonary embolism and other acute thrombotic disorders, where it effectively promotes the dissolution of fibrin clots.