抗人 UPF2 抗体对
01AB01409
UPF2 regulator of nonsense mediated mRNA decay (UPF2) is a key component of the nonsense-mediated mRNA decay (NMD) pathway, which serves as a quality control mechanism to eliminate mRNAs containing premature stop codons. UPF2 is part of a post-splicing multiprotein complex, interacting with UPF1 and UPF3 proteins, and plays a central role in the formation of the surveillance complex that recognizes and degrades faulty mRNAs. It acts as an adaptor between Stau1 and UPF1, stimulating UPF1's catalytic activity and facilitating mRNA nuclear export and surveillance. UPF2 is primarily located in the perinuclear region and is expressed in various tissues, including the brain, where it has been implicated in regulating synaptic spine density and neuronal plasticity. Alterations in UPF2 function can impact neural processes and behavior, suggesting a potential link to neurodevelopmental or neuropsychiatric conditions.
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技术参数
- 靶点基因名
- UPF2
- 基因别名
- KIAA1408; RENT2
- 蛋白别名
- UPF2 regulator of nonsense mediated mRNA decay; UPF2
- UniProt
- Q9HAU5
- 物种
- Human
产品详情
- 靶点名称
- UPF2
- 蛋白名称
- UPF2 regulator of nonsense mediated mRNA decay
- 蛋白别名
- Regulator of nonsense transcripts 2; Up-frameshift suppressor 2 homolog; hUpf2
- 靶点基因名
- UPF2
- 基因别名
- KIAA1408; RENT2
- UniProt
- Q9HAU5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
UPF2 regulator of nonsense mediated mRNA decay (UPF2) is a key component of the nonsense-mediated mRNA decay (NMD) pathway, which serves as a quality control mechanism to eliminate mRNAs containing premature stop codons. UPF2 is part of a post-splicing multiprotein complex, interacting with UPF1 and UPF3 proteins, and plays a central role in the formation of the surveillance complex that recognizes and degrades faulty mRNAs. It acts as an adaptor between Stau1 and UPF1, stimulating UPF1's catalytic activity and facilitating mRNA nuclear export and surveillance. UPF2 is primarily located in the perinuclear region and is expressed in various tissues, including the brain, where it has been implicated in regulating synaptic spine density and neuronal plasticity. Alterations in UPF2 function can impact neural processes and behavior, suggesting a potential link to neurodevelopmental or neuropsychiatric conditions.