人 UNC5D 抗体对
01AB02357
Unc-5 netrin receptor D (UNC5D) is a type I transmembrane receptor that primarily binds netrin-4 to regulate axon guidance, neuronal migration, and cell-cell adhesion. In the developing nervous system, UNC5D mediates the repulsion of neuronal growth cones and directs the radial migration of cortical neurons. Functioning as a dependence receptor, it promotes cell survival when engaged by its ligand; however, in the absence of netrin or following DNA damage, the receptor is cleaved by caspases to trigger apoptosis via its intracellular death domain. This dual role makes UNC5D a critical regulator of programmed cell death. Clinically, UNC5D expression is a significant prognostic marker in neuroblastoma, where its involvement in a p53/E2F1-linked pro-apoptotic loop is associated with favorable clinical outcomes.
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技术参数
- 靶点基因名
- UNC5D
- 基因别名
- KIAA1777; UNC5H4
- 蛋白别名
- unc-5 netrin receptor D; UNC5D
- UniProt
- Q6UXZ4
- 物种
- Human
产品详情
- 靶点名称
- UNC5D
- 蛋白名称
- unc-5 netrin receptor D
- 蛋白别名
- Netrin receptor UNC5D; Protein unc-5 homolog 4; Protein unc-5 homolog D
- 靶点基因名
- UNC5D
- 基因别名
- KIAA1777; UNC5H4
- UniProt
- Q6UXZ4
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Unc-5 netrin receptor D (UNC5D) is a type I transmembrane receptor that primarily binds netrin-4 to regulate axon guidance, neuronal migration, and cell-cell adhesion. In the developing nervous system, UNC5D mediates the repulsion of neuronal growth cones and directs the radial migration of cortical neurons. Functioning as a dependence receptor, it promotes cell survival when engaged by its ligand; however, in the absence of netrin or following DNA damage, the receptor is cleaved by caspases to trigger apoptosis via its intracellular death domain. This dual role makes UNC5D a critical regulator of programmed cell death. Clinically, UNC5D expression is a significant prognostic marker in neuroblastoma, where its involvement in a p53/E2F1-linked pro-apoptotic loop is associated with favorable clinical outcomes.