抗人 UNC5C 抗体对
01AB01405
Unc-5 netrin receptor C (UNC5C) is a transmembrane protein belonging to the UNC-5 family of netrin receptors. It plays a crucial role in axon guidance and neuronal migration during neural development. UNC5C contains two immunoglobulin-like domains and two thrombospondin motifs in its extracellular region, along with ZU5, UPA, and death domains in its cytoplasmic portion. The protein mediates axon repulsion in response to netrin-1 binding and can induce apoptosis when not bound to its ligand. UNC5C interacts with microtubules and is involved in regulating cell survival and axon repulsion. Recent studies have associated UNC5C variants with Alzheimer's disease, and the gene has been implicated in various cancers. Additionally, mutations in UNC5C have been linked to psychiatric disorders.
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技术参数
- 靶点基因名
- UNC5C
- 基因别名
- UNC5H3
- 蛋白别名
- unc-5 netrin receptor C; UNC5C
- UniProt
- O95185
- 物种
- Human
产品详情
- 靶点名称
- UNC5C
- 蛋白名称
- unc-5 netrin receptor C
- 蛋白别名
- Netrin receptor UNC5C; Protein unc-5 homolog 3; Protein unc-5 homolog C
- 靶点基因名
- UNC5C
- 基因别名
- UNC5H3
- UniProt
- O95185
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Unc-5 netrin receptor C (UNC5C) is a transmembrane protein belonging to the UNC-5 family of netrin receptors. It plays a crucial role in axon guidance and neuronal migration during neural development. UNC5C contains two immunoglobulin-like domains and two thrombospondin motifs in its extracellular region, along with ZU5, UPA, and death domains in its cytoplasmic portion. The protein mediates axon repulsion in response to netrin-1 binding and can induce apoptosis when not bound to its ligand. UNC5C interacts with microtubules and is involved in regulating cell survival and axon repulsion. Recent studies have associated UNC5C variants with Alzheimer's disease, and the gene has been implicated in various cancers. Additionally, mutations in UNC5C have been linked to psychiatric disorders.