人 UGDH 抗体对
01AB02047
UDP-glucose 6-dehydrogenase (UGDH) is a cytosolic, homohexameric oxidoreductase that catalyzes the NAD+-dependent oxidation of UDP-glucose to UDP-α-D-glucuronate. This product is the essential precursor for glucuronidation and the biosynthesis of glycosaminoglycans, including hyaluronan, chondroitin sulfate, and heparan sulfate. These glycans are vital components of the extracellular matrix, supporting embryonic development, cell migration, and tissue repair. Clinically, inherited loss-of-function variants in UGDH are linked to early-onset epileptic encephalopathy, highlighting its role in neurodevelopment. In oncology, UGDH-driven overproduction of hyaluronan is associated with tumor progression, metastasis, and poor prognosis in various epithelial cancers. Consequently, UGDH serves as both a molecular marker and a potential therapeutic target for inhibiting the invasive properties of cancer cells and modulating the tumor microenvironment.
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技术参数
- 靶点基因名
- UGDH
- 蛋白别名
- UDP-glucose 6-dehydrogenase; UGDH
- UniProt
- O60701
- 物种
- Human
产品详情
- 靶点名称
- UGDH
- 蛋白名称
- UDP-glucose 6-dehydrogenase
- 蛋白别名
- UDP-glucose 6-dehydrogenase; UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH
- 靶点基因名
- UGDH
- UniProt
- O60701
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
UDP-glucose 6-dehydrogenase (UGDH) is a cytosolic, homohexameric oxidoreductase that catalyzes the NAD+-dependent oxidation of UDP-glucose to UDP-α-D-glucuronate. This product is the essential precursor for glucuronidation and the biosynthesis of glycosaminoglycans, including hyaluronan, chondroitin sulfate, and heparan sulfate. These glycans are vital components of the extracellular matrix, supporting embryonic development, cell migration, and tissue repair. Clinically, inherited loss-of-function variants in UGDH are linked to early-onset epileptic encephalopathy, highlighting its role in neurodevelopment. In oncology, UGDH-driven overproduction of hyaluronan is associated with tumor progression, metastasis, and poor prognosis in various epithelial cancers. Consequently, UGDH serves as both a molecular marker and a potential therapeutic target for inhibiting the invasive properties of cancer cells and modulating the tumor microenvironment.