抗人 UCHL5 抗体对
01AB00975
Ubiquitin C-terminal hydrolase L5 (UCHL5), encoded by the UCHL5 gene, is a deubiquitinating enzyme (DUB) belonging to the ubiquitin C-terminal hydrolase family. It hydrolyzes ubiquitin-protein bonds, regulating protein degradation via the ubiquitin-proteasome system (UPS). UCHL5 interacts with the 19S regulatory particle of the 26S proteasome, facilitating substrate deubiquitination during proteasomal processing. Structurally, it contains a catalytic domain critical for its hydrolase activity and a C-terminal extension enabling proteasome binding. UCHL5 also participates in DNA repair, cell cycle regulation, and NF-κB signaling by modulating ubiquitin dynamics. Dysregulation of UCHL5 is linked to cancer progression, including multiple myeloma, where its overexpression enhances proteasome activity and chemoresistance. Additionally, altered UCHL5 expression is implicated in neurodegenerative disorders, potentially due to UPS dysfunction. Validated substrates include BRCA1-associated protein 1 (BAP1), highlighting its role in tumor suppression pathways.
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技术参数
- 靶点基因名
- UCHL5
- 基因别名
- UCH37
- 蛋白别名
- ubiquitin C-terminal hydrolase L5; UCHL5
- UniProt
- Q9Y5K5
- 物种
- Human
产品详情
- 靶点名称
- UCHL5
- 蛋白名称
- ubiquitin C-terminal hydrolase L5
- 蛋白别名
- Ubiquitin carboxyl-terminal hydrolase isozyme L5; UCH-L5; Ubiquitin C-terminal hydrolase UCH37; Ubiquitin thioesterase L5
- 靶点基因名
- UCHL5
- 基因别名
- UCH37
- UniProt
- Q9Y5K5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ubiquitin C-terminal hydrolase L5 (UCHL5), encoded by the UCHL5 gene, is a deubiquitinating enzyme (DUB) belonging to the ubiquitin C-terminal hydrolase family. It hydrolyzes ubiquitin-protein bonds, regulating protein degradation via the ubiquitin-proteasome system (UPS). UCHL5 interacts with the 19S regulatory particle of the 26S proteasome, facilitating substrate deubiquitination during proteasomal processing. Structurally, it contains a catalytic domain critical for its hydrolase activity and a C-terminal extension enabling proteasome binding. UCHL5 also participates in DNA repair, cell cycle regulation, and NF-κB signaling by modulating ubiquitin dynamics. Dysregulation of UCHL5 is linked to cancer progression, including multiple myeloma, where its overexpression enhances proteasome activity and chemoresistance. Additionally, altered UCHL5 expression is implicated in neurodegenerative disorders, potentially due to UPS dysfunction. Validated substrates include BRCA1-associated protein 1 (BAP1), highlighting its role in tumor suppression pathways.