抗人 UBE4A 抗体对
01AB01400
Ubiquitination factor E4A (UBE4A) is a human protein encoded by the UBE4A gene located on chromosome 11 and functions primarily as a ubiquitin-protein ligase, likely acting as both an E3 and E4 ligase in the ubiquitination pathway. UBE4A is involved in the assembly of multiubiquitin chains, a critical step in targeting abnormal or short-lived proteins for proteasomal degradation, thereby maintaining protein quality control within the cell. The protein interacts with other ubiquitination machinery components, such as E1 and E2 enzymes, and has been shown to catalyze the ubiquitination of specific substrates, including NRF1, facilitating its processing and regulating cellular stress responses. Structurally, UBE4A contains domains characteristic of ubiquitin ligases and displays multiple isoforms due to alternative splicing, with its molecular features and interaction partners mapped in protein databases. Mutations or dysregulation of UBE4A have been linked to neurodevelopmental disorders and may play a role in cancer progression, such as influencing p53 expression in colorectal cancer.
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技术参数
- 靶点基因名
- UBE4A
- 基因别名
- KIAA0126
- 蛋白别名
- ubiquitination factor E4A; UBE4A
- UniProt
- Q14139
- 物种
- Human
产品详情
- 靶点名称
- UBE4A
- 蛋白名称
- ubiquitination factor E4A
- 蛋白别名
- Ubiquitin conjugation factor E4 A; RING-type E3 ubiquitin transferase E4 A
- 靶点基因名
- UBE4A
- 基因别名
- KIAA0126
- UniProt
- Q14139
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ubiquitination factor E4A (UBE4A) is a human protein encoded by the UBE4A gene located on chromosome 11 and functions primarily as a ubiquitin-protein ligase, likely acting as both an E3 and E4 ligase in the ubiquitination pathway. UBE4A is involved in the assembly of multiubiquitin chains, a critical step in targeting abnormal or short-lived proteins for proteasomal degradation, thereby maintaining protein quality control within the cell. The protein interacts with other ubiquitination machinery components, such as E1 and E2 enzymes, and has been shown to catalyze the ubiquitination of specific substrates, including NRF1, facilitating its processing and regulating cellular stress responses. Structurally, UBE4A contains domains characteristic of ubiquitin ligases and displays multiple isoforms due to alternative splicing, with its molecular features and interaction partners mapped in protein databases. Mutations or dysregulation of UBE4A have been linked to neurodevelopmental disorders and may play a role in cancer progression, such as influencing p53 expression in colorectal cancer.